Wolfram syndrome Summary The Wolfram syndrome is a rare disorder with an autosomal recessive inheritance. The symptoms develop as a consequence of a progressive neurodegenerative process.
The first manifestation of the syndrome is a childhood onset diabetes mellitus followed by diabetes insipidus, optic nerve atrophy, hearing impairment, and dilation of the urinary tract each case in a different sequence. Treatment of the disease is determined by the current symptoms.
By virtue of its multifacetedness, it requires the concerted actions of care from different professions. Bennett, PH: Classification and diagnosis of diabetes mellitus and impaired glucose tolerance.
In: Textbook of diabetes. Harris, MI, Zimmet, P: Classification of diabetes mellitus and other categories of glucose intolerance. In: International textbook of diabetes mellitus.
Orv Hetil Ann Cukorbetegek étrendje táblázat Q J Med Lancet Neurology Am J Dis Child Diabetes Diabetes insipidus type 2 6: Diabetes Care 9: Diabetes Care Brit J Urol Lancet 1: Diab Res Clin Pract J Inher Metab Dis Am J Hum Genet J Med Genet Nature Genet 8: ,