Does diabetic gastroparesis cause constipation. Diabetes-Related Dysfunction of the Small Intestine and the Colon: Focus on Motility

University of Aarhus Rövid összefoglaló Background: Gastrointestinal GI symptoms are overrepresented in patients with diabetes mellitus DM and often have a major impact on quality of life. Typical symptoms of diabetic enteropathy include abdominal pain, nausea, vomiting, diarrhoea, constipation, faecal incontinence, and bloating.

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Bowel symptoms in DM are usually caused by widespread dysfunction of the GI tract, but the exact pathophysiology remains incompletely understood.

Within recent years, new methods for detailed assessment of GI motility have been developed.

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Hence, the electromagnetic 3D-Transit system is a safe, non-invasive method for detailed description of GI motility. The system tracks the exact position of an ingested electromagnetic capsule through the entire GI tract and provides detailed information on both regional transit- and contraction patterns.

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The HRCM is however an invasive method, as the catheter is placed during colonoscopy. HRCM does diabetic gastroparesis cause constipation not previously been performed on diabetic patients and 3D-Transit has only been used sparingly.

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Study Objectives: The purpose of this study is to obtain detailed description of colonic contractions in patients with DM and gastrointestinal symptoms, especially during fast and after meals.

Hypothesis: 1.

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The contractile response to a meal is reduced in patients with symptoms of diabetic enteropathy when compared to healthy controls. Data will be compared to the healthy from another study CIV For 24 hours, the participants lie in a bed in the research lab while pressure changes from the HRCM catheter are recorded and the 3D-Transit capsules are followed through the gastrointestinal system.

Perspectives: The study will add to the very limited data available on colonic dysfunction in DM. Átfogó állapot.

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