Type 1 diabetes investigations,
Type 1 Diabetes Mellitus (DM) – Endocrinology - Lecturio
A glykaemiás kontroll és a szövődmények kialakulásának összefüggése terén alapvető ismeretekhez jutottunk az 1-es típusú diabetesben szenvedők körében végzett DCCT Diabetes Control and Complications Trialilletve a 2-es típusú cukorbetegek körében folytatott UKPDS United Kingdom Prospective Diabetes Study alapadatainak és utánkövetésének publikációjakor. Ezek a megfigyelések — többek között — megalapozták a metabolikus memória, illetve a metabolikus örökség fogalmát.
A közlemény az áttekintett vizsgálatok fontosabb eredményeit összegzi. Orv Hetil.
Abstract: The effect of antihyperglycaemic antidiabetic treatment on the late diabetic complications is one of the most important research areas in clinical diabetology. In these studies, observational follow-up investigations were also performed after the close-out of the randomized phase of the trial.
Summary Introduction: Diabetes mellitus DM leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide NO — soluble guanylate cyclase sGC — cyclic guanosine monophosphate cGMP signaling. Cardio-protective effects of elevated intracellular cGMP-levels have been described in different heart diseases. In the current study we aimed at investigating the effects of pharmacological activation of sGC in diabetic cardiomyopathy. Methods: Type-1 DM was induced in rats by streptozotocin. Left ventricular LV pressure-volume P-V analysis was used to assess cardiac performance.
In addition to these landmark studies, type 1 diabetes investigations randomized, controlled efficacy trials were also performed with observational follow-up investigations resulting in the development of the concept of metabolic memory or metabolic legacy. In this article, the main results of the studies are summarized.
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